Disintegrant, normally used in 2% concentration in tablets made by direct compression and 3% by wet granulation. White or grayish-white powder, practically insoluble in anhydrous ethanol. Hygroscopic. Insoluble in water but rapidly swells in it to four to eight times the original volume. Density in bulk 0.53 g/ml. pH 5–7 in an aqueous slurry.
The detrimental effect of high relative humidity on XPVP is attributed to the high absorption of moisture which acts as a plasticiser for the disintegrant in the dry state, causing, in turn, a premature release of the energy stored within the compressed disintegrant particles and an increase in tablet thickness (i.e. shape-recovery in the dry ...
The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. An oral solid dosage form should ideally disperse into the primary particles from which it was prepared. Tablets and capsules which need rapid disintegration, the inclusion of the right …
An Overview of Disintegrants. The ability of the active ingredient in a drug to be absorbed by the body depends on its bioavailability. This, in turn, is a function of the solubility of the active ingredient in the gastrointestinal fluids as the drug passes through the intestines. The ability to dissolve depends on the physical form and ...
The most accepted mechanism for tablet disintegration is by disintegrant swelling.8, 12 Swelling is associated with dimensional amplification where particles enlarge omni-directionally to push apart the adjoining components, thereby initiating the break-up of the tablet matrix (). 13 Most popular disintegrants swell to some extent and swelling …