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The T244I variant of the interleukin-7 receptor-alpha gene …
The findings in the sample support previous reported association studies between IL7RA rs6897932 and MS, and include Europeans and Americans of European origin resulting in stronger association with similar OR. Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor …
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Association between the IL7R T244I polymorphism and
Regarding MS susceptibility and the polymorphism, studies which met the following criteria were identified: (1) Clinical case–control or cohort studies concentrated on the role of …
Association between the IL7R T244I polymorphism and
The association of IL7R T244I polymorphism and MS. Meta-analysis for the association between IL7R T244I polymorphism and MS under dominant genetic model (CC vs. TT) in the total populations using a random-effects model. The squares and horizontal lines correspond to the study specific OR and 95 % CI.
Interleukin 7 receptor T244I polymorphism and the
The IL7R T244I creates a non-conservative amino acid change on position 244(Ile → Thr) and leads to an increase of skipping of exon six (Teutsch et al., 2003). IL7R gene …
Association between the IL7R T244I polymorphism and …
The aim of this study was to explore the association between the IL7R T244I polymorphism (rs6897932) and susceptibility of multiple sclerosis (MS). A comprehensive literature search for relevant studies was conducted on Google scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM).
Association between the IL7R T244I polymorphism and …
Abstract Previously published analyses of the association between the interleukin 7 receptor (IL7R) T244I polymorphism (rs6897932) and multiple sclerosis (MS) have yielded conflicting results. We performed a meta-analysis to assess whether the combined data showed this association, and to investigate its effect size.
RET T244I Germline Variant Mutation in a Patient with …
Genetic testing revealed a variant of uncertain significance within the RET gene [c.731C>T (p.T244I)]. Conclusions: Paragangliomas are rare extra-adrenal neuroendocrine tumors that can be associated with germline mutations. Our patient was diagnosed with a pancreatic paraganglioma associated with a RET T244I mutation.
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The T244I variant of the interleukin-7 receptor-alpha gene …
Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor-alpha gene (IL7RA), rs6897932. We …
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Mutation overview page OR5C1
This section shows a general overview of the selected mutation. It describes the source of the mutation i.e gene name/sample name/tissue name with unique ID, and also shows the mutation syntax at the amino acid and nucleotide sequence level.
Genetic variants in IL2RA and IL7R affect multiple sclerosis …
The p.T244I variant, genotyped in this study, has been shown to affect alternative splicing of IL7R exon 6 and alter the amounts of soluble and membrane-bound protein, thus suggesting a …
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Association between the IL7R T244I polymorphism and …
In MS, the IL7R T244I (rs6897932) single nucleotide polymorphism (SNP) is most likely the causative variant. T244I is located within exon 6 of IL7R, within a transmembrane …
Interleukin 7 receptor T244I polymorphism and the …
DOI: 10.1016/j.jneuroim.2020.577166 Corpus ID: 210846658; Interleukin 7 receptor T244I polymorphism and the multiple sclerosis susceptibility: a meta-analysis @article{SahamiFard2020Interleukin7R, title={Interleukin 7 receptor T244I polymorphism and the multiple sclerosis susceptibility: a meta-analysis}, author={Mohammad Hossein Sahami-Fard …
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The T244I variant of the interleukin-7 receptor-alpha gene …
Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor-alpha gene (IL7RA), rs6897932. We performed a new replication case-control study in 599 MS patients and 594 healthy controls, all Caucasians from the south of Spain.
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Assessment of IL-7RA T244I Polymorphism as a Risk Factor …
Introduction: The T244I variant of the IL-7RA gene, rs6897932, is one of the first polymorphisms found to be associated with the development of multiple sclerosis (MS). Although several studies provided evidence for the association of MS and this variant, other studies could not confirm this result.
Interleukin 7 receptor T244I polymorphism and the …
Background: Multiple sclerosis (MS) is recognized as the most prevalent chronic inflammatory neurological disorder diagnosed in young adults. Recent evidence suggests that …
Interleukin 7 receptor T244I polymorphism and the
IL7R T244I (rs6897932) is one of the polymorphisms that has been studied its role in the risk of MS. This variant is located in exon 6 of the IL7R gene, within a transmembrane area of the encoded protein, on chromosome 5p13.8–15.
Interleukin 7 receptor T244I polymorphism and the …
IL7R T244I (rs6897932) is one of the polymorphisms that has been studied its role in the risk of MS. This variant is located in exon 6 of the IL7R gene, within a transmembrane area …
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YouTube Won't Ban A Guy Who Crushes Animals to Death …
Among the many prolific channels on YouTube is bootsmade4crushing (BM4C) which for four years has featured videos of someone using expensive boots to stomp and crush everything from...
Association between the IL7R T244I polymorphism and …
The aim of this study was to explore the association between the IL7R T244I polymorphism (rs6897932) and susceptibility of multiple sclerosis (MS). A comprehensive literature search …
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